Anti-Mouse CD32/CD16 – FITC
Anti-Mouse CD32/CD16 – FITC
Product No.: C249
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Clone 2.4G2 Target CD32/CD16 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names Fcγ II/III Receptor Isotype IgG1 Applications FA , FC |
Data
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Antibody DetailsProduct DetailsReactive Species Mouse Host Species Rat Product Concentration 0.2 mg/ml Formulation This Fluorescein (FITC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This Fluorescein conjugate is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day Ambient Excitation Laser Blue Laser (490 nm) RRIDAB_2829547 Applications and Recommended Usage? Quality Tested by Leinco FC The suggested concentration for this 2.4G2 antibody for staining cells in flow cytometry is ≤ 1 μg per 106 cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application. Additional Reported Applications For Relevant Conjugates ? B For specific conjugates of this clone, review literature for suggested application details. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone 2.4G2 recognizes the FcγIII and FcγII receptors. Background CD16 is expressed in two forms: CD16a and CD16b. CD16a (FcγRIIIA) is a 50-65 kD polypeptide-anchored transmembrane protein. CD16b (FcγRIIIB) is a 48 kD GPI-anchored protein whose extracellular domain is over 95% homologous to that of CD16a. CD16 regulates both phagocytosis and antibody-dependent cell-mediated cytotoxicity. It has been reported that CD16 is involved in Natural Killer Cell activation and plays a role in signal transduction. The receptors, CD32 (FcγRIII) and CD16 (FcγRII), are 40-60 kD and bind antibody-antigen immune complexes and mediate adaptive immune responses. Antigen Distribution These receptors are present on B cells, monocyte/macrophages, NK cells, neutrophils, mast cells and dendritic cells. Ligand/Receptor IgG PubMed UniProt.org Research Area Immunology . Innate Immunity References & Citations1. Titas, J. A. et al. (1982) J. Immunol. 133:556
2. Rodewald, H. et al. (1992) Cell 69:139 Technical ProtocolsFA  Certificate of Analysis |
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
