Anti-Mouse CD54 (Clone YN1/1.7.4) – DyLight® 594
Anti-Mouse CD54 (Clone YN1/1.7.4) – DyLight® 594
Product No.: C2399
- -
- -
Clone YN1/1.7.4 Target CD54 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names Ly-47, ICAM-1 Isotype IgG2b κ Applications FC |
- -
- -
Antibody DetailsProduct DetailsReactive Species Mouse Host Species Rat Product Concentration 0.2 mg/ml Formulation This DyLight® 594 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This DyLight® 594 conjugate is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C Excitation Laser Red Laser (590 nm) RRIDAB_2829493 Applications and Recommended Usage? Quality Tested by Leinco FC The suggested concentration for this YN1/1.7.4 antibody for staining cells in flow cytometry is ≤ 1.0 μg per 106 cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application. Additional Reported Applications For Relevant Conjugates ? B IHC (Frozen) For specific conjugates of this clone, review literature for suggested application details. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone YN1/1.7.4 recognizes an epitope on mouse CD54. Background ICAM-1 is a 55 kDa glycoprotein that is part of the Ig superfamily. It is heavily glycosylated to form 75 kDa to 115 kDa. ICAM-1 is known to be an adhesion and viral entry molecule, and its long suspected involevement in signal transduction is being elucidated. The signal-transducing functions of ICAM-1 appear to be mainly associated with proinflammatory pathways. Furthermore, ICAM-1 signaling appears to act as a beacon for inflammatory immune cells such as macrophages and granulocytes bringing about inflammation via lymphocyte trafficking. ICAM-1 is essential for the transmigration of leukocytes out of blood vessels and into tissues, and is a marker of endothelial dysfunction leading to damaging vascular disorders in umbilical and placental vascular tissue of gestational pregnancies. ICAM-1 is the receptor for rhinoviruses (the cause of most common colds) and malaria, and plays an inflammatory role in ocular allergies. Antigen Distribution CD54 is present on endothelial cells, lymphocytes, epithelial cells, dendritic cells and keratinocytes. Ligand/Receptor CD11a/CD18 (LFA-1) or CD11b/CD18 (Mac-1) and CD11c/CD18, CD43, hyaluronan, fibrinogen PubMed NCBI Gene Bank ID UniProt.org Research Area Cell Adhesion . Cell Biology . Costimulatory Molecules . Immunology . Innate Immunity . Neuroscience . Neuroscience Cell Markers . Stem Cell References & Citations1. Li, S. et al. (2009) Biochem. Biophys. Res. Commun. 381: 459
2. Wolf, S. et al. (2009) Pharmacol. Rep. 61: 22
3. Ozcan, U. et al. (2009) Arch Gynecol. Obstet. Technical Protocols Certificate of Analysis |
Formats Available
- -
- -
Prod No. | Description |
|---|---|
C2401 | |
C2396 | |
C2151 | |
C2392 | |
C2394 | |
C2393 | |
C2397 | |
C2398 | |
C2399 | |
C2400 | |
C2395 | |
C527 | |
C2391 | |
C6391 |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
