Anti-Mouse CD71 (Transferrin Receptor) – DyLight® 550
Anti-Mouse CD71 (Transferrin Receptor) – DyLight® 550
Product No.: C1926
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Clone R17217 Target CD71 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names Transferrin Receptor Isotype IgG2a Applications FC |
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Antibody DetailsProduct DetailsReactive Species Mouse Host Species Rat Immunogen Purified Recombinant Mouse CD71 (>98%) Product Concentration 0.2 mg/ml Formulation This DyLight® 550 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This DyLight® 550 conjugate is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C Excitation Laser Yellow Laser (563 nm) RRIDAB_2829006 Applications and Recommended Usage? Quality Tested by Leinco FC The suggested concentration for this R17217 antibody for staining cells in flow cytometry is ≤ 0.5 μg per 106 cells in a volume of 100 μl. Titration of the reagent is recommended for optimal performance for each application. Additional Reported Applications For Relevant Conjugates ? B For specific conjugates of this clone, review literature for suggested application details. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone R17217 recognizes an epitope on CD71. Background CD71 is a 95 kD type II homodimeric transmembrane glycoprotein. The function of CD71 is believed to be primarily nutritional. It plays a role in the control of cellular proliferation through facilitation of iron uptake by way of ferrotransferrin binding and the recycling of apotransferrin to the cell surface. Additionally, transferrin receptor is required for erythropoiesis and proper neurological development, and it has also been suggested that a growth signal might be generated by the transferrin/transferrin receptor interaction. Current genetic analysis indicates that the structural genes for transferrin receptor and for a melanoma-associated antigen (p97), and perhaps transferrin itself, each map to a common chromosome in humans. These proteins exhibit primary sequence homology with transferrin and have the ability to bind ferric iron. Therefore, it is thought that genetic rearrangements in this iron transport region may be associated with malignant transformation. Hence, anti-CD71 mAbs are thought to have therapeutic potential in cases of human leukemia & lymphoma. Antigen Distribution CD71 is expressed on most proliferating cells, activated lymphocytes, monocytes, macrophages, erythroid progenitors, and brain endothelium. Ligand/Receptor Transferrin. NCBI Gene Bank ID UniProt.org Research Area Immunology References & Citations1. Lesley, J. et al. (1982) Immunogenetics 15:313 2. Lesley, J. et al. (1984) Mol. Cell. Biol. 4(9):1675 3. Kemp, JD. et al. (1987) J. Immunol. 138:2422 4. Kemp, JD. et al. (1989) Cell Immunol. 122:218 Technical Protocols Certificate of Analysis |
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
