Anti-Mouse CTLA-4 (CD152) – Purified in vivo GOLD™ Functional Grade
Anti-Mouse CTLA-4 (CD152) – Purified in vivo GOLD™ Functional Grade
Product No.: C2860
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Clone UC10-4F10-11 Target CTLA-4 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names CD152, Cytotoxic T Lymphocyte-Associated Antigen-4, Ly-56 Isotype IgG1 κ Applications FA , FC , in vivo , IP , WB |
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Antibody DetailsProduct DetailsReactive Species Mouse Host Species Armenian Hamster Recommended Isotype Controls Recommended Dilution Buffer Immunogen Purified Recombinant Mouse CTLA4 Fc Fusion Protein Product Concentration ≥ 5.0 mg/ml Endotoxin Level < 1.0 EU/mg as determined by the LAL method Purity ≥95% monomer by analytical SEC ⋅ >95% by SDS Page Formulation This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration. Product Preparation Functional grade preclinical antibodies are manufactured in an animal free facility using in vitro cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates. Storage and Handling Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at -80°C. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day 2-8°C RRIDAB_2829616 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone UC10-4F10-11 recognizes an epitope on mouse CTLA-4. Background CTLA-4 is a 33 kD member of the Ig superfamily similar to CD28 in amino acid sequence, structure, and genomic organization. CTLA-4 is a protein receptor that functions as an immune checkpoint and downregulates immune responses. It is involved in the development of protective immunity and thymocyte regulation, in addition to the induction and maintenance of immunological tolerance. CTLA-4 has therapeutic potential both as an agonist to reduce immune activity, and an antagonist to increase immune activity. Antigen Distribution CTLA-4 is expressed on activated T and B lymphocytes. Ligand/Receptor CD80 (B7-1), CD86 (B7-2) Function Negative regulator of T cell activation NCBI Gene Bank ID UniProt.org Research Area Immunology . Inhibitory Molecules References & CitationsTechnical ProtocolsFA     Certificate of Analysis |
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Formats Available
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
