Anti-Mouse/Human Interleukin-5 (IL-5) – PE
Anti-Mouse/Human Interleukin-5 (IL-5) – PE
Product No.: I-1064
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Clone TRFK5 Target IL-5 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names BCDFII,Interleukin-5, IL5, B cell differentiation factor 1, TRF, EDF Isotype IgG1 κ Applications FC , ICC |
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Antibody DetailsProduct DetailsReactive Species Mouse Host Species Rat Immunogen Partially-purified T cell clone supernatant Product Concentration 0.2 mg/ml Formulation This R-phycoerythrin (R-PE) conjugate is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative. Product Preparation The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions in accordance to our in-house quality systems SOPBR's. Storage and Handling This R-PE conjugated antibody is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C Excitation Laser Blue Laser (488 nm) Green Laser (532 nm)/Yellow-Green Laser (561 nm) RRIDAB_2830397 Applications and Recommended Usage? Quality Tested by Leinco Flow Cytometry:This antibody can be used at a concentration of ≤ 0.5 µg per 100 µl of whole blood (or per 1.0 x 106 cells in a 100 µl total staining volume). Each lot of this antibody is quality control tested. Additional Applications Reported In Literature ? Additional reported applications (for the relevant formats) include: ELISA Neutralization Western Blotting IHC-FFPE IHC-FF Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone TRFK5 recognizes mouse/human IL-5. Background IL-5 is a 26 kD TH2 cytokine and a homodimeric glycoprotein that is part of the hematopoietic family. IL-5 stimulates B cell growth as well as increases Ig secretion. It is the main factor that promotes the terminal differentiation of eosinophil progenitors and enhances the effector capacity of mature eosinophils. IL-5 is a major regulator of eosinophil accumulation in tissues. In fact, in Hodgkin lymphoma, the characteristically observed eosinophilia is suspected to result from an increased production of IL-5. IL-5 may also be the cause of several allergic diseases including asthma, where it is thought that eosinophils have a significant role in the disease pathology. There are several mAbs currently in use that target IL-5 for the treatment of severe eosinophilic asthma. Antigen Distribution Mast cells, T cells, eosinophils Function Growth/differentiation of B cells, eosinophils; proliferation/cell activation/differentiation of eosinophilic granulocytes PubMed UniProt.org References & CitationsTechnical Protocols ICC Certificate of Analysis |
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
