Anti-Mouse IFNAR-1 (Clone MAR1-5A3) – Purified
Anti-Mouse IFNAR-1 (Clone MAR1-5A3) – Purified
Product No.: I-400
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Clone MAR1-5A3 Target IFNAR1 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names CD118, Ifar, Ifnar, Ifrc, INF-a receptor, Interferon-α/β receptor α chain precursor Isotype IgG1 Applications B , ELISA , FC , IP , WB |
Data
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Antibody DetailsProduct DetailsReactive Species Mouse Host Species Mouse Immunogen This antibody was produced by In vivo genetic immunization of IFNAR1 knockout mice with a plasmid encoding the extracellular domain of murine IFNAR1. Product Concentration 0.5 mg/ml Formulation This purified antibody is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This purified antibody is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C RRIDAB_2830666 Applications and Recommended Usage? Quality Tested by Leinco FC The suggested concentration for clone MAR1-5A3 antibody for staining cells in flow cytometry is ≤ 2.0 μg per 106 cells in a volume of 100 μl or 100μl of whole blood. Titration of the reagent is recommended for optimal performance for each application. Additional Applications Reported In Literature ? WB IP B ELISA Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone MAR1-5A3 recognizes an epitope on mouse IFNAR1. Background IFNAR1 is a type I membrane protein, that in conjunction with IFNAR2, makes up the heterodimeric receptor that binds all type I IFNs, which includes IFN α and β. Binding and activation of the receptor stimulates Janus protein kinases, which leads to the phosphorylation of several other proteins, namely STAT1 and STAT2. IFNAR1 has also been shown to interact with PRMT1 and Tyrosine kinase 2. Type I IFNs are a family of cytokines that have been shown to promote anti-viral, anti-microbial, anti-tumor and autoimmune responses In vivo. Antigen Distribution IFNAR1 and IFNAR2 are coexpressed on nearly all cells. Ligand/Receptor IFN-α/β NCBI Gene Bank ID UniProt.org References & Citations1. Sheehan, K. C. F. et al. (2006) JICR 26(11):804 2. Dunn, G. P. et al. (2005) Nat. Immunol. 6(7):722 3. Fenner, J. E. et al. (2006) Nat. Immunol. 7(1):33 Technical ProtocolsB     Certificate of Analysis |
Formats Available
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Prod No. | Description |
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I-400 | |
I-1014 | |
I-1018 | |
I-402 | |
I-401 | |
I-1033 | |
I-1032 | |
I-1188 |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
