Anti-Mouse IL-2 (Clone JES6-1A12) – DyLight® 594
Anti-Mouse IL-2 (Clone JES6-1A12) – DyLight® 594
Product No.: I-1089
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Clone JES6-1A12 Target IL-2 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names TCGF, Lymphokine, T-Cell Growth Factor, IL2, EDF, KHF, MAF-C 1, TDF Isotype IgG2a κ Applications FC , ICC |
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Antibody DetailsProduct DetailsReactive Species Mouse Host Species Rat Immunogen Purified Recombinant Mouse IL-2 (>98%) Product Concentration 0.2 mg/ml Formulation This DyLight® 594 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This DyLight® 594 conjugate is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C Excitation Laser Red Laser (590 nm) RRIDAB_2830424 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone JES6-1A12 recognizes an epitope on mouse IL-2. Background IL-2 is a 17.2 kD cytokine signaling protein that is the regulator of the proliferative and suppressive phases of the immune response, and stimulates growth and differentiation of B cells, NK cells, LAK cells, monocytes, and oligodendrocytes. It functions as a primary regulator of T cell homeostasis. Il-2 regulates the activities of white blood cells and plays a role in the immune system via “self” and “non-self” discrimination. IL-2 is a prime candidate in immunotherapeutics for both increasing T cell levels/function and for augmenting vaccine-elicited viral-specific T cell responses. IL-2 signal can be transduced via 3 different signaling pathways that include the JAK-STAT, PI3K/Akt/mTOR and MAPK/ERK pathways. Aldesleukin is a form of recombinant interleukin-2 for the treatment of cancers including malignant melanoma and renal cell cancer. Furthermore, there is additional therapeutic potential for IL-2 mAb use with transplants and autoimmune disease. PubMed NCBI Gene Bank ID UniProt.org Research Area Immunology . Other Molecules References & Citations1. Schachter, J. et al. (2009) Cytotherapy 11: 206 2. Sodora, DL. et al. (2009) Curr HIV Res. 7: 83 3. Alcocer-Varela, J. et al. (2009) Autoimmun Rev. 9(1):34-9. Technical ProtocolsCertificate of Analysis |
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