Anti-Mouse IL-4 (Clone BVD6-24G2) – Biotin
Anti-Mouse IL-4 (Clone BVD6-24G2) – Biotin
Product No.: I-1109
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Clone BVD6-24G2 Target IL-4 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names BCGF, BCDF, B Cell Stimulating Factor, BSF-1, IaIF, HCGF, MCGF2, MFF, TCGF-2 Isotype IgG1 Applications ELISA , ELISA Det , ELISPOT Det |
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Antibody DetailsProduct DetailsReactive Species Mouse Host Species Rat Immunogen Purified Recombinant Mouse IL-4 (>98%) Product Concentration 0.5 mg/ml Formulation This biotinylated antibody is formulated in 0.01 M phosphate buffered saline (PBS) pH 7.4, 150 mM NaCl, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This Biotin conjugate is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C RRIDAB_2830444 Applications and Recommended Usage? Quality Tested by Leinco ELISA:Each lot of this antibody is quality control tested by ELISA assay. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone BVD6-24G2 recognizes an epitope on mouse IL-4. Background IL-4 is a 15-19 kD pleiotropic immune cytokine secreted by activated TH2 cells. It has many biological roles, including the regulation in humoral and adaptive immunity, the inhibition of bone resorption, the stimulation of activated B-cell and T-cell proliferation, and initiation of allergic responses. Moreover, IL-4 induces a positive feedback loop by stimulating differentiation of naive helper T cells, or Th0 cells, to Th2 cells which in turn secrete more IL-4. Increased IL-4 production and overproduction of IL-4R are found in many cancers. IL-4 has a significant effect on tumor progression by increasing apoptosis resistance via tumor growth enhancement. IL-4 may also play a part in the immune dysregulation that occurs in most HIV-1 infected patients. Matched Pair Clone BVD6-24G2 can be used as the capture antibody in a sandwich ELISA or ELISPOT, using biotinylated clone 11B11 for detection. PubMed NCBI Gene Bank ID UniProt.org Research Area Cell Biology . Stem Cell . Other Molecules References & Citations1. Pike, JW. et al. (2001) PNAS 98: 2443 2. Finkelman, FD. et al. (2003) J Immunol. 170: 3835 3. Kaplan, MH. et al. (2008) J Immunol. 180: 3551 Technical Protocols ELISA Det ELISPOT Det Certificate of Analysis |
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Formats Available
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Prod No. | Description |
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I-1109 | |
I-1108 |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
