Anti-Mouse IL-4 (Clone 11B11) – DyLight® 488
Anti-Mouse IL-4 (Clone 11B11) – DyLight® 488
Product No.: I-1077
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Clone 11B11 Target IL-4 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names Interleukin-4, BCGF, BCDF, B Cell Stimulating Factor, BSF-1, IaIF, HCGF, MCGF2, MFF, TCGF-2 Isotype IgG1 κ Applications ICFC |
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Antibody DetailsProduct DetailsReactive Species Mouse Host Species Rat Immunogen Partially Purified Native Mouse IL-4 Product Concentration 0.2 mg/ml Formulation This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This DyLight® 488 conjugate is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C Excitation Laser Blue Laser (493 nm) RRIDAB_2830411 Additional Applications Reported In Literature ? ICFC Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone 11B11 recognizes an epitope on mouse IL-4. Background IL-4 antibody, 11B11, recognizes mouse IL-4, also known as B-cell differentiation factor (BCDF) and B-cell stimulatory factor (BSF1). IL-4 is a pleiotropic 20 kDa cytokine secreted by T helper 2 cells (Th2) cells, natural killer T (NKT) cells, mast cells, eosinophils, and basophils1,2. IL-4 signaling through the IL-4 receptor alpha chain (IL-4Ra) induces the differentiation of naive T cells to Th2 cells3,4 and stimulates B cell differentiation, proliferation, and class switching to IgG1 and IgE isotypes5. In addition, IL-4 is implicated in normal wound healing6,7 and airway inflammation in patients with asthma8. Antigen Distribution IL-4 is secreted by Th2 cells, NKT cells, mast cells, eosinophils, and basophils. PubMed NCBI Gene Bank ID UniProt.org Research Area Immunology . Other Molecules References & Citations1. Yoshimoto T & Paul WE. (1994) J Exp Med. 179(4):1285–95 2. Kipnis J., at al. (2012) J Immunol. 189(9):4213-4219 3. Groth B., et al. (1992) J Exp Med. 176:1091–8 4. Murphy KM., et al. (1992) Proc Natl Acad Sci USA. 89:6065–9 5. Paul WE., et al. (1999) Annual Rev Immunol. 17:701-38 6. Maquart FX., et al. (2000) Lab Invest. 80(8):1337-43 7. Godeau, G., et al. (2000) Lab Invest. 80,1337–1343 8. Steinke JW & Borish L. (2001) Respir Res. 2(2):66-70 |
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
