Anti-Mouse Leptin R (Clone 55305)

Purified Recombinant Mouse Leptin Receptor (>98%)

This monoclonal antibody has been 0.2 µm filtered and lyophilized from modified Dulbecco's phosphate buffered saline (1X PBS) pH 7.2 - 7.3 containing 5.0% w/v trehalose with no calcium, magnesium or preservatives present.

The lyophilized antibody can be stored desiccated at -20°C to -70°C for up to twelve months. The reconstituted antibody can be stored for at least four weeks at 2-8°C. For long-term storage of the reconstituted antibody, aseptically aliquot into working volumes and store at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. No detectable loss of activity was observed after six months.

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Rat Anti-Mouse Leptin Receptor (Clone 55305) recognizes an epitope on Mouse Leptin Receptor. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Leptin receptor, also known as LEPR, and CD295 (cluster of differentiation 295) is a single-transmembrane-domain receptor of the cytokine-receptor family.¹ Leptin receptor exists in multiple forms with a common extracellular domain and a variable length cytoplasmatic portion. Leptin receptor may act as a negative regulator of Leptin activity and it may maintain a pool of available bioactive Leptin by binding and delaying its clearance from circulation. Leptin receptor is considered a physiological marker of primate fetal lung maturity.²

1. Guy-Grand, B. et al.(1998) Nature 392: 398
2. Castracane, VD. et al.(2004) Reproduction 127: 87