Anti-Mouse Ly-6G – FITC
Anti-Mouse Ly-6G – FITC
Product No.: L282
- -
- -
Clone 1A8 Target Ly-6G Formats AvailableView All Product Type Monoclonal Antibody Alternate Names Lymphocyte Antigen 6 Complex, Ly6G Isotype IgG2a Applications FC |
- -
- -
Antibody DetailsProduct DetailsReactive Species Mouse Host Species Rat Immunogen Purified Recombinant Mouse Ly-6G (>98%) Product Concentration 0.2 mg/ml Formulation This Fluorescein (FITC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This Fluorescein (FITC) conjugate is stable when stored at 2-8°C.Do not freeze. Country of Origin USA Shipping Next Day 2-8°C Excitation Laser Blue Laser (490 nm) RRIDAB_2831192 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone 1A8 recognizes an epitope on mouse Ly6G. Clone 1A8 does not cross react with Ly6C. Background Ly6G antibody, clone 1A8, recognizes lymphocyte antigen 6 complex locus G6D (Ly6G; also called Gr-1), a 21-25 kDa glycosylphosphatidylinositol (GPI)-anchored protein1. Ly6G belongs to the lymphocyte antigen-6 (Ly6)/urokinase-type plasminogen activator receptor (uPAR) superfamily, characterized by a Ly6/uPAR (LU) domain-containing a three-fingered structural motif stabilized by disulfide bonds2. Ly6G is expressed by murine neutrophils regardless of location and activation1,4,5. Eosinophils may also express low levels of Ly6G5. There is no human ortholog for Ly6G; however, a structurally related L76/uPAR protein, CD177 (also known as HNA-2a, NB1, or PRV-1) is expressed in human neutrophils and is implicated in neutropenia6. Although the exact function and ligand of Ly6G remain unknown, Ly6G ligation may impair neutrophil migration to sites of inflammation via a β2-integrin-dependent mechanism7. Antigen Distribution Ly6G is expressed by neutrophils. PubMed NCBI Gene Bank ID UniProt.org Research Area Immunology . Innate Immunity References & Citations1. Fleming TJ, at al. (1993) J Immunol. 151(5):2399-408 2. Tsetlin VI. (2015) Trends Pharmacol Sci. 36(2):109-23 3. Daley JM, et al. (2008) J Leukoc Biol. 83(1):64-70 4. Lee PY, et al. (2013) J Leukoc Biol. 94(4):585-594 5. Percopo CM, et al. (2017) J Leukoc Biol. 101(1):321-328. 6. Stroncek DF. (2007) Curr Opin Hematol. 14(6):688-93 7. Wang JX, et al. (2012) Blood. 120(7):1489-1498 Technical ProtocolsCertificate of Analysis |
Formats Available
- -
- -
Prod No. | Description |
---|---|
L286 | |
L279 | |
L283 | |
L282 | |
L285 | |
L281 | |
L287 | |
L288 | |
L289 | |
L500 | |
L280 | |
L284 | |
L305 |
![Disclaimer Alert Disclaimer Alert](/wp-content/themes/Avada-Child-Theme/disclaimer.jpg)