Anti-Mouse MAdCAM-1 (MECA-367) – DyLight® 488
Anti-Mouse MAdCAM-1 (MECA-367) – DyLight® 488
Product No.: M1406
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Clone MECA-367 Target MADCAM-1 Formats AvailableView All Product Type Monoclonal Antibody Isotype IgG2a Applications FC |
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Antibody DetailsProduct DetailsReactive Species Mouse Host Species Rat Immunogen Mouse Endothelial Cells Product Concentration 0.2 mg/ml Formulation This DyLight® 488 conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This DyLight® 488 conjugate is stable when stored at 2-8°C. Do not freeze. Regulatory Status Research Use Only Country of Origin USA Shipping 2 - 8°C Wet Ice Excitation Laser Blue Laser (493 nm) RRIDAB_2831339 Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Rat Anti-Mouse MAdCAM-1 (Clone MECA-367) recognizes an epitope on Mouse MAdCAM-1. This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype. Background Mucosal vascular addressin cell adhesion molecule 1 (MAdCAM-1) is a multifunctional type l transmembrane adhesion molecule that is expressed selectively at venular sites of lymphocyte extravasation into mucosal lymphoid tissues and lamina propria, where it directs local lymphocyte trafficking.1 MAdCAM-1 is involved in the normal recirculation of lymphocytes between the blood and the gastrointestinal tract.2 MAdCAM-1 may be a relevant tissue-specific therapeutic target for the modulation of inflammatory bowel disease activity.3 Ligand/Receptor Integrin a4ß7, CD62L PubMed NCBI Gene Bank ID UniProt.org Research Area Cell Adhesion . Cell Biology . Immunology References & Citations1. Briskin MJ et al. (1995) J Immunol. 155: 2477
2. Jackson D et al. (1997) Immunol Res. 16: 299
3. Ringler DJ et al. (1997) Am J Pathol. 151: 97 Technical Protocols Certificate of Analysis |
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
