Anti-Mouse/Rat CD71 – APC
Anti-Mouse/Rat CD71 – APC
Product No.: C869
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Clone OX-26 Target CD71 Formats AvailableView All Product Type Monoclonal Antibody Alternate Names Transferrin Receptor, T9 Isotype IgG2a κ Applications FC |
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Antibody DetailsProduct DetailsReactive Species Mouse/Rat Host Species Mouse Immunogen PHA-activated rat lymph node cells Product Concentration 0.2 mg/ml Formulation This Allophycocyanin (APC) conjugate is formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.4, 1% BSA and 0.09% sodium azide as a preservative. Storage and Handling This Allophycocyanin (APC) conjugate is stable when stored at 2-8°C. Do not freeze. Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco FC IHC Additional Applications Reported In Literature ? IHC FC Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Clone OX-26 reacts with rat CD71 (TfR1). Background CD71 is a transferrin receptor on the cell surface that mediates the uptake of transferrin-iron complexes, thereby mediating cellular proliferation1. CD71 is a homodimeric glycoprotein containing 760 amino acids and it binds to diferric transferrin2. Binding by diferric transfferin causes CD71 to be internalized, and diferric iron is subsequently released3. CD71 is highly expressed on malignant cells, as iron uptake is necessary for aberrant cell proliferation4. Antigen Distribution CD71 is expressed on the surface of proliferating cells, reticulocytes, and erythroid precursors. Ligand/Receptor Transferrin UniProt.org Research Area Immunology References & Citations1. Aisen P. Int J Biochem Cell Biol. Nov;36(11):2137-43. 2004.
2. Lawrence CM, Ray S, Babyonyshev M, et. al. Science. Oct 22;286(5440):779-82. 1999. 3. Marsee DK, Pinkus GS, Yu H. Am J Clin Pathol. Sep;134(3):429-35. 2010. 4. Candelaria PV, Leoh LS, Penichet ML, Daniels-Wells TR. Front Immunol. Mar 17;12:607692. 2021 5. Jiménez E, Sacedón R, Vicente A, et. al. J Immunol. May 15;168(10):5005-13. 2002. 6. Fabriek BO, Polfliet MM, Vloet RP, et. al. Blood. Jun 15;109(12):5223-9. 2007. Technical Protocols Certificate of Analysis |
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C853 | |
C869 |
Formats Available
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
