Anti-Mouse Receptor Interacting Protein 3 (RIP3)

PN:R1008

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-Mouse Receptor Interacting Protein 3 (RIP3) recognizes Mouse and Rat RIP3. This polyclonal antibody was purified using affinity chromatography.

Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3.^1-3 RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-kB activation. Overexpression of RIP3 induces apoptosis and NF-κB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues.^2,3

1. Yu, PW. et al. (1999) Curr. Biol. 9(10):539
2. Sun, X. et al. (1999) J. Biol. Chem. 274(24):16871
3. Pazdernik, NJ. et al. (1999) Mol. Cell Bio. 19(10):6500