Anti-PAPK Antibody (28107)
Anti-PAPK Antibody (28107)
Product No.: 28107
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Target PAPK Product Type Polyclonal Alternate Names STRAD β, Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein homolog, ILP-interacting protein homolog, Polyploidy-associated protein kinase, Pseudokinase ALS2CR2 Applications WB |
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Antibody DetailsProduct DetailsReactive Species Mouse Host Species Rabbit Immunogen Synthetic peptide corresponding to amino acids 399-418 (SPWSELEFQFPDDKDPVWEF) of mouse PAPK conjugated to KLH at the C-terminus. Product Concentration Lot Specific Formulation PBS, pH 7.4. State of Matter Liquid Product Preparation Purified by peptide immuno-affinity chromatography Storage and Handling This antibody is stable for at least one (1) year at -20°C. Avoid multiple freeze- thaw cycles. Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco Immunoblotting: use at 1:250 dilution. A band of approximately 46-47 kDa is detected.
Positive control: liver tissue lysate. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionDescriptionSpecificity Rabbit Polyclonal Antibody specific to PAPK (ALS2CR2) Background PAPK (polyploidy-associated protein kinase) is a new member of the Ste20/germinal center kinase family that modulates cytoskeletal organization and cell survival. Activation of a death signal transduction pathway may result in the stimulation of the PAPK promoter which leads to increased PAPK expression and provides a negative feedback signal that prevents cell death. Another name for this protein is ALS2CR2 (amyotrophic lateral sclerosis 2 chromosome region candidate 2, isoform A). Function Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity). {ECO:0000250}. NCBI Gene Bank ID UniProt.org Research Area Neuroscience References & CitationsNishigaki, K et al. (2003) J Biol Chem 15: 13520-30. Technical Protocols Certificate of Analysis |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
