Anti-PfHsp70 Antibody (11147)

His-tagged C-terminal amino acids 365-681 of P. falciparum Hsp70 (Accession no. M19753).

PBS, pH 7.4, 50% glycerol, 0.09% sodium azide. Purified by Protein A affinity chromatography.

Liquid

Purified by Protein A affinity chromatography

This antibody is stable for at least one (1) year at -20°C.

For in vitro investigational use only. Not intended for diagnostic or therapeutic applications.

Next Day 2-8°C

This antibody recognizes P. falciparum Hsp70.

Plasmodium falciparum expresses two prominent heat shock proteins: heat shock protein 70 (PfHsp70) and heat shock protein 90 (PfHsp90). Both of these proteins have been implicated in the development and pathogenesis of malaria. PfHsp70-1 is the major cytosolic Hsp70 in Plasmodium falciparum. It is abundantly expressed in the blood stages of the parasite and appears to constitute approx. 1-2% of total parasite protein. It is found in P. falciparum in complexes with PfHsp90 and PfHsp40. The transition from the cold blooded mosquito vector to a host represents physiological stress to the parasite, and, additionally, malaria blood stage infection is characterized by intense fever periods. In recent years, it has become clear that heat shock proteins play an essential role during the parasite's life cycle.