Anti-Prostaglandin E Synthase Antibody (13809)
Anti-Prostaglandin E Synthase Antibody (13809)
Product No.: 13809
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Target Prostaglandin E Synthase Product Type Polyclonal Alternate Names EC 5.3.99.3, Glutathione peroxidase PTGES, EC 1.11.1.-, Glutathione transferase PTGES, EC 2.5.1.18, Microsomal glutathione S-transferase 1-like 1, MGST1-L1, Microsomal prostaglandin E synthase 1, MPGES-1, p53-induced gene 12 protein Applications IHC , IHC-P |
Data
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Antibody DetailsProduct DetailsReactivity Species Human Host Species Rabbit Immunogen Synthetic peptide conjugated to KLH. Product Concentration Lot Specific Formulation PBS containing 0.1% sodium azide State of Matter Liquid Product Preparation Purified by peptide immuno-affinity chromatography Storage and Handling This antibody is stable at 4°C (short- term) and -70°C (long-term). Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco Immunohistochemistry: Use at 10ug/ml.Testis: Formalin-fixed, paraffin-embedded Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionSpecificity Rabbit Polyclonal Antibody specific to Prostaglandin E Synthase Background Prostaglandin E Synthase (PGES) is a membrane associated protein involved in eicosanoid and glutathione metabolism as part of the arachidonic acid signaling pathway. PGES expression is induced by the proinflammatory cytokine IL-1B, and its activity is glutathione dependent. PGES is also expressed at high levels in p53- expressing cells. Antigen DetailsFunction Terminal enzyme of the cyclooxygenase (COX)-2-mediated prostaglandin E2 (PGE2) biosynthetic pathway. Catalyzes the glutathione-dependent oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2) in response to inflammatory stimuli (PubMed:18682561, PubMed:10377395, PubMed:12672824, PubMed:12460774, PubMed:10869354, PubMed:12244105). Plays a key role in inflammation response, fever and pain (By similarity). Catalyzes also the oxidoreduction of endocannabinoids into prostaglandin glycerol esters and PGG2 into 15-hydroperoxy-PGE2 (PubMed:12244105, PubMed:12672824). In addition, displays low glutathione transferase and glutathione-dependent peroxidase activities, toward 1-chloro-2,4-dinitrobenzene and 5-hydroperoxyicosatetraenoic acid (5-HPETE), respectively (PubMed:12672824). {UniProtKB:Q9JM51, PubMed:10377395, PubMed:10869354, PubMed:12244105, PubMed:12460774, PubMed:12672824, PubMed:18682561}. NCBI Gene Bank ID UniProt.org Research Area Enzymes References & Citations IHC-P |
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