Anti-SARS-CoV-2 Spike (CT)

Anti-SARS-CoV-2 (COVID-19, 2019-nCoV) Spike antibody was raised against a peptide corresponding to 20 amino acids near the carboxy terminus of SARS-CoV-2 (COVID-19, 2019-nCoV) Spike glycoprotein. The immunogen is located within the last 50 amino acids of SARS-CoV-2 (COVID-19, 2019-nCoV) Spike protein.

This polyclonal antibody is formulated in phosphate buffered saline (PBS) pH 7.4 containing 0.02% sodium azide as a preservative.

This polyclonal antibody is stable for at least one week when stored at 2-8°C. For long term storage, aliquot in working volumes without diluting and store at –20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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Rabbit Anti-SARS-CoV-2 recognizes an epitope near the C-terminus of SARS-CoV-2 Spike. This polyclonal antibody was purified using affinity chromatography.

A coronavirus, SARS-CoV-2 was first identified in 2019 (COVID-19). Coronaviruses are a major cause of upper respiratory diseases in humans. The genomes of these viruses are positive-stranded RNA approximately 27-31kb in length. SARS-CoV-2 can be mediated by the binding of the viral spike protein, a glycosylated protein and the major surface antigen of the virus, to the angiotensin-converting enzyme 2 (ACE2) on target cells. This binding can be blocked by a soluble form of ACE2.

1. Gorbalenya. bioRxiv: (2020). 2. Hui et al. Int J Infect Dis. (2020);91:264-266. 3. Belouzard et al. Viruses. (2012);4(6):1011-33. 4. Lee et al. J Virol. (2006);80(8):4079-87. 5. Wan et al. J Virol. (2020). 6. Wrapp et al. Science. (2020).