Anti-Superoxide dismutase 1 Antibody (13064)

Anti-Superoxide dismutase 1 Antibody (13064)

Product No.: 13064


Target Superoxide dismutase 1 Product Type Polyclonal Alternate Names EC 1.15.1.1, Superoxide dismutase 1, hSod1 Applications ELISA , IHC , WB


Select Product Size 100 µg — $478.00	Qty Max: Min: 1 Step: 1 $478.00 ADD TO CART Login For mAb Advantage Pricing Contact Us for Bulk Quantities

Data

Western blot analysis of Mouse Lung showing detection of ~18 kDa SOD1 (EDI) protein using Rabbit Anti-SOD1 (EDI) Polyclonal Antibody (13064). Lane 1: Molecular Weight Ladder. Lane 2: Mouse Lung. Load: 20 µg. Primary Antibody: Rabbit Anti-SOD1 (EDI) Polyclonal Antibody (13064) at 1:1000. Predicted/Observed Size: ~18 kDa.


Antibody Details Product Details Reactive Species Human ⋅ Mouse ⋅ Rat Host Species Rabbit Immunogen Peptide corresponding to exposed dimer interface (EDI) region at the N-terminus of SOD1. Product Concentration Lot Specific Formulation PBS, pH 7.4, 50% glycerol, 0.09% sodium azide. State of Matter Liquid Product Preparation Purified by peptide affinity chromatography Storage and Handling This antibody is stable for at least one (1) year at -20°C. Regulatory Status For in vitro investigational use only. Not intended for diagnostic or therapeutic applications. Country of Origin USA Shipping Next Day 2-8°C Applications and Recommended Usage? Quality Tested by Leinco Immunoblotting: use at 1ug/mL. A band of ~18kDa is detected. These are recommended concentrations. Endusers should determine optimal concentrations for their applications. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. Description Description Specificity This antibody recognizes human, mouse, and rat SOD1. Background Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme that catalyzes the dismutation of the superoxide radical O2- to oxygen and hydrogen peroxide which are then metabolized to H2O and O2 by catalase and glutathione peroxidase. SODs play an important role in antioxidant defense mechanisms. Three different SOD isoenzymes are found in mammalian cells: SOD1, SOD2, and SOD3. SOD1 contains Cu and Zn ions and exists as a homodimer in cell cytoplasm. The two subunits of ~16kDa each are linked by two cysteines that form an intrasubunit disulfide bridge. Misfolding of SOD1 has been implicated in Amyotrophic Lateral Sclerosis (ALS). Function Destroys radicals which are normally produced within the cells and which are toxic to biological systems. {PubMed:24140062}. NCBI Gene Bank ID SOD1 UniProt.org P00441 Research Area Enzymes References & Citations View product citations for antibody PRODUCT_CODE on CiteAb Technical Protocols Certificate of Analysis Request COA

Antibody Details

Product Details

Reactive Species

Human

⋅

Mouse

⋅

Rat

Host Species

Rabbit

Immunogen

Peptide corresponding to exposed dimer interface (EDI) region at the N-terminus of SOD1.

Product Concentration

Lot Specific

Formulation

PBS, pH 7.4, 50% glycerol, 0.09% sodium azide.

State of Matter

Liquid

Product Preparation

Purified by peptide affinity chromatography

Storage and Handling

This antibody is stable for at least one (1) year at -20°C.

Regulatory Status

For in vitro investigational use only. Not intended for diagnostic or therapeutic applications.

Country of Origin

USA

Shipping

Next Day 2-8°C

Applications and Recommended Usage?
Quality Tested by Leinco

Immunoblotting: use at 1ug/mL. A band of ~18kDa is detected.

These are recommended concentrations.

Endusers should determine optimal concentrations for their applications.

Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change.

Description

Specificity

This antibody recognizes human, mouse, and rat SOD1.

Background

Superoxide dismutase (SOD) is an endogenously produced intracellular enzyme that catalyzes the dismutation of the superoxide radical O2- to oxygen and hydrogen peroxide which are then metabolized to H2O and O2 by catalase and glutathione peroxidase. SODs play an important role in antioxidant defense mechanisms. Three different SOD isoenzymes are found in mammalian cells: SOD1, SOD2, and SOD3. SOD1 contains Cu and Zn ions and exists as a homodimer in cell cytoplasm. The two subunits of ~16kDa each are linked by two cysteines that form an intrasubunit disulfide bridge. Misfolding of SOD1 has been implicated in Amyotrophic Lateral Sclerosis (ALS).

Function

Destroys radicals which are normally produced within the cells and which are toxic to biological systems. {PubMed:24140062}.

NCBI Gene Bank ID

SOD1

UniProt.org

P00441

Research Area

Enzymes