Caspase-12 (Intermediate Domain) Blocking Peptide
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Antibody DetailsProduct DetailsReactive Species Mouse Product Concentration 0.2 mg/ml Amino Acid Location This peptide sequence is located at amino acids 100 to 116 of Mouse Caspase-12 protein. Formulation This peptide is formulated in PBS pH 7.2 (0.01 M Sodium Phosphate, 0.13 M NaCl) containing 0.1% bovine serum albumin and 0.02% sodium azide. Storage and Handling Store this peptide in working aliquots at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient Amino Acid Sequence 17 amino acids near the center of mouse Caspase-12. Each investigator should determine their own optimal working dilution for specific applications. See directions on lot specific datasheets, as information may periodically change. DescriptionBackground Caspase-12 peptide is applicable as a control peptide for blocking antibody binding in Western blotting. References & Citations1. Matsushima M, Fujiwara T, Takahashi E, et al. Isolation, mapping, and functional analysis of a novel human cDNA (BNIP3L) encoding a protein homologous to human NIP3. Genes Chromosomes Cancer 1998;21:230-5
2.Yasuda M, Han JW, Dionne CA, Boyd JM, Chinnadurai G. BNIP3α: a human homolog of mitochondrial proapoptotic protein BNIP3. Cancer Res 1999;59:533-7
3. Chen G, Cizeau J, Vande Velde C, et al. Nix and Nip3 form a subfamily of pro-apoptotic mitochondrial proteins. J Biol Chem 1999;274(1):7-10
4. Imazu T, Shimizu S, Tagami S, et al. Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability. Oncogene. 1999;18:4523-9 (RD1200)
5. Nakagawa T, Zhu H, Morishima N, Li E, Xu J, Yankner BA, Yuan J. Caspase-12 mediates endoplasmicreticulum-specific apoptosis and cytotoxicity by amyloid -beta. Nature 2000;403:98-103. |
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