Recombinant Human E-Selectin

E-selectin, also known as CD62E is an inducible leukocyte adhesion glycoprotein specifically expressed by endothelial cells.¹ E-selectin helps initiate recruitment of circulating leukocytes to cutaneous, bone and inflamed tissues.² E-selectin is found in inflammatory skin lesions in psoriasis, contact dermatitis, and delayed- type hypersensitivity, in arthritic joints, and in heart and renal allografts undergoing rejection.³ E-selectin-targeting antibody drug conjugate has potential as a prostate cancer therapy.⁴

Fc Fusion Protein

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Trp22

Lyophilized

The predicted molecular weight of Recombinant Human E-Selectin is Mr 86 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 150 kDa.

86

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Milstone, D. et al. (2004) PNAS 101: 8005
2. Dimitroff, CJ. et al. (2009) J Visualized Experiments
3. Hirata, T. et al. (2005) J Immunol. 175: 8042
4. Vanitha, R. et al. (2003) Cancer Res. 63: 6387