Recombinant Human FGF R1β (IIIb)

Product No.: F1052


Alternate Names CEK, FLG, OGD, FLT2, KAL2, BFGFR, CD331, FGFBR, HBGFR, N-SAM, FLJ99988, FGFR1 Product Type Recombinant Protein Expression Host NS0 Cells Species Human Applications ELISA Cap


Select Product Size 50 µg — $460.00	Qty Max: Min: 1 Step: 1 $460.00 ADD TO CART Login For mAb Advantage Pricing Contact Us for Bulk Quantities


Background Fibroblast growth factor receptor-1 beta (FGFR1- beta) is an isoform of FGFR1 which is a receptor tyrosine kinase. FGFR1-beta is expressed in basal epithelial cells and smooth muscle cells.¹ FGF R1β supports progression and chemoresistance in subsets of acute myeloid leukemias (AML).² Protein Details Purity >95% by SDS-PAGE and analyzed by silver stain. Endotoxin Level <0.1 EU/µg as determined by the LAL method Biological Activity The biological activity of Human FGF R1β (IIIb) was determined by its ability to inhibit FGF acidic-dependent proliferation of NR6R-3T3 mouse fibroblasts. The expected ED<sub>50</sub> is 1 - 3 ng/ml. Fusion Protein Tag Fc Fusion Protein Protein Accession No. NP_075594 Amino Acid Sequence Human FGF R1β (IIIb) (Arg22 - Lys221) - 47 aa IIIb Ig domain (His1 - Pro47) - Human FGF R1β (IIIb) (Ala269 - Glu285) - IEGRDMD - Human IgG1 (Pro100 - Lys330) N-terminal Sequence Analysis Arg22 State of Matter Lyophilized Predicted Molecular Mass The predicted molecular weight of Recombinant Human FGF R1β (IIIb) is Mr 56 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 90-100 kDa. Predicted Molecular Mass 56 Storage and Stability This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. Country of Origin USA Shipping Next Day Ambient NCBI Gene Bank 2260 References & Citations 1. Moscatelli, D. et al. (2007) Prostate 67: 115 2. Raffi, S. et al. (2006) Leukemia 20: 979 View product citations for antibody PRODUCT_CODE on CiteAb Technical Protocols Certificate of Analysis Request COA IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.

Background

Fibroblast growth factor receptor-1 beta (FGFR1- beta) is an isoform of FGFR1 which is a receptor tyrosine kinase. FGFR1-beta is expressed in basal epithelial cells and smooth muscle cells.¹ FGF R1β supports progression and chemoresistance in subsets of acute myeloid leukemias (AML).²

Protein Details

Purity

>95% by SDS-PAGE and analyzed by silver stain.

Endotoxin Level

<0.1 EU/µg as determined by the LAL method

Biological Activity

The biological activity of Human FGF R1β (IIIb) was determined by its ability to inhibit FGF acidic-dependent proliferation of NR6R-3T3 mouse fibroblasts. The expected ED<sub>50</sub> is 1 - 3 ng/ml.

Fusion Protein Tag

Fc Fusion Protein

Protein Accession No.

NP_075594

Amino Acid Sequence

Human FGF R1β (IIIb) (Arg22 - Lys221) - 47 aa IIIb Ig domain (His1 - Pro47) - Human FGF R1β (IIIb) (Ala269 - Glu285) - IEGRDMD - Human IgG1 (Pro100 - Lys330)

N-terminal Sequence Analysis

Arg22

State of Matter

Lyophilized

Predicted Molecular Mass

The predicted molecular weight of Recombinant Human FGF R1β (IIIb) is Mr 56 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 90-100 kDa.

Predicted Molecular Mass

Storage and Stability

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Country of Origin

USA

Shipping

Next Day Ambient

NCBI Gene Bank

2260

References & Citations

1. Moscatelli, D. et al. (2007) Prostate 67: 115
2. Raffi, S. et al. (2006) Leukemia 20: 979

View product citations for antibody PRODUCT_CODE on CiteAb

Certificate of Analysis

Request COA

IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.

Prod No.	Description
F1043	Recombinant Human FGF R1β (IIIc)
F1052	Recombinant Human FGF R1β (IIIb)

Products are for research use only. Not for use in diagnostic or therapeutic procedures.

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Recombinant Human FGF R1β (IIIb)