Recombinant Human Flt-3

Fms-Like tyrosine kinase 3 (FLT3) is a member of the class III tyrosine kinase receptor family, normally expressed in hematopoietic, immune and neural systems.¹ FLT3 is expressed in various lymphohematopoietic cells and tissues, including a series of immature cell lines and leukemias of lymphocytic origin.² FLT3 is a promising target for the therapeutic intervention for acute leukemias, particularly acute myeloid leukemia (AML) which are severe and aggressive malignancy.¹

Fc Fusion Protein

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Asn27

Lyophilized

The predicted molecular weight of Recombinant Human Flt-3 is Mr 85.5 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 120 kDa.

85.5

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Botta, M. et al. (2008) Curr Med Chem. 15: 3113
2. Birnbaum, D. et al. (1993) Blood 82: 1110