Recombinant Human GDF-15

Growth differentiation factor 15 (GDF15) is a protein belonging to the transforming growth factor beta superfamily that has a role in regulating inflammatory and apoptotic pathways in injured tissues and during disease processes.¹ GDF15 is also known as TGF-PL, MIC-1, PDF, PLAB, and PTGFB.² GDF15 is predominantly expressed in the liver, with lower levels seen in some other tissues. Its expression in the liver is significantly up-regulated during injury of organs such as liver, kidney, heart and lung.^1,2,3 GDF-15 is a promising new biomarker in idiopathic pulmonary arterial hypertension.⁴

Histidine Tag

arngdhcplg pgrccrlhtv rasledlgwa dwvlsprevq vtmcigacps qfraanmhaq iktslhrlkp dtvpapccvp asynpmvliq ktdtgvslqt yddllakdch cihhhhhh

His & Asn199

Lyophilized

The predicted molecular weight of Recombinant Human MIC-1 is Mr 13 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 14 kDa.

13

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Koniaris, L. et al. (2005) Shock 23: 543
2. Lee, S. et al. (2000) Mol Cell Biol 20: 3742
3. Sadoshima, J. et al. (2006) Circ Res 98 : 294
4. Wollert KC. et al. (2008)Am J Respir Crit Cre Med. 178 : 534