Recombinant Human IFN-γ R1
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BackgroundIFN-γ receptor ligand-binding chain (IFNγR1) or IFN-γ R α chain, also known CDw119, is member of the class II cytokine receptor family. The IFN-γ receptor is a complex of a high affinity IFN-γ-binding chain (aka, IFN-γ R α chain) and a second accessory protein required for signal transduction known as IFN-γ R β chain. Binding of IFN-γ induces receptor dimerization and internalization. Signal transduction involves Jak1 and Jak2 protein kinases and involves STAT1 activation. The IFN-γ receptor is expressed at moderate levels on virtually every cell with the exception of erythrocytes.1,2,3 Protein DetailsPurity >95% by SDS-PAGE and analyzed by silver stain. Endotoxin Level <1.0 EU/µg as determined by the LAL method Protein Accession No. Amino Acid Sequence emg tadlgpssvp tptnvtiesy nmnpivywey qimpqvpvft vevknygvkn sewidacini shhycnisdh vgdpsnslwv rvkarvgqke sayakseefa vcrdgkigpp kldirkeekq imidifhpsv fvngdeqevd ydpettcyir vynvyvrmng seiqykiltq keddcdeiqc qlaipvssln sqycvsaegv lhvwgvttek skevcitifn ssikg & g tadlgpssvp tptnvtiesy nmnpivywey qimpqvpvft vevknygvkn sewidacini shhycnisdh vgdpsnslwv rvkarvgqke sayakseefa vcrdgkigpp kldirkeekq imidifhpsv fvngdeqevd ydpettcyir vynvyvrmng seiqykiltq keddcdeiqc qlaipvssln sqycvsaegv lhvwgvttek skevcitifn ssikg N-terminal Sequence Analysis Glu18 & Gly20 State of Matter Lyophilized Predicted Molecular Mass The predicted molecular weight of Recombinant Human IFN-γ R1 is Mr 25 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 40 and 50 kDa. Predicted Molecular Mass 25 Formulation This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives. Storage and Stability This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. Country of Origin USA Shipping Next Day Ambient NCBI Gene Bank References & Citations1. Calderon, J. et al. (1988) PNAS 85: 4837 2. Garcia-Sastre, G. et al. (2002) Int. Rev. Immunol. 21: 305 3. Fish, E. et al. (2002) J. Interferon Cytokine Res. 22: 835 Certificate of AnalysisIMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein. |
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.