Recombinant Human IGF-I sR

Recombinant Human IGF-I sR

Product No.: I-560

[product_table name="All Top" skus="I-560"]

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Alternate Names
Insulin-Like Growth Factor I Soluble Receptor, CD221, IGFIR, JTK13, MGC142170, MGC142172, MGC18216
Product Type
Recombinant Protein
Expression Host
NS0 Cells
Species
Human

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Select Product Size
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Background

Insulin-like Growth Factor 1 (IGF-1) Receptor is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection.1 IGF-1 receptor may be a central regulator of mammalian lifespan2 and when activated, it results in survival and proliferation in mitosis-competent cells, and growth (hypertrophy) in tissues such as skeletal muscle and cardiac muscle. IGF1R is now an attractive anti-cancer treatment target.1

Protein Details

Purity
>95% by SDS Page and analyzed by silver stain.
Endotoxin Level
<0.1 EU/µg as determined by the LAL method
Protein Accession No.
Amino Acid Sequence

mksgsgggsp tslwgllfls aalslwptsg eicgpgidir ndyqqlkrle nctviegylh illiskaedy rsyrfpkltv iteylllfrv agleslgdlf pnltvirgwk lfynyalvif emtnlkdigl ynlrnitrga irieknadlc ylstvdwsli ldavsnnyiv gnkppkecgd lcpgtmeekp mcekttinne ynyrcwttnr cqkmcpstcg kractennec chpeclgscs apdndtacva crhyyyagvc vpacppntyr fegwrcvdrd fcanilsaes sdsegfvihd gecmqecpsg firngsqsmy cipcegpcpk vceeekktkt idsvtsaqml qgctifkgnl linirrgnni aselenfmgl ievvtgyvki rhshalvsls flknlrlilg eeqlegnysf yvldnqnlqq lwdwdhrnlt ikagkmyfaf npklcvseiy rmeevtgtkg rqskgdintr nngerasces dvlhftsttt sknriiitwh ryrppdyrdl isftvyykea pfknvteydg qdacgsnswn mvdvdlppnk dvepgillhg lkpwtqyavy vkavtltmve ndhirgakse ilyirtnasv psipldvlsa snsssqlivk wnppslpngn lsyyivrwqr qpqdgylyrh nycskdkipi rkyadgtidi eevtenpkte vcggekgpcc acpkteaekq aekeeaeyrk vfenflhnsi fvprperkrr dvmqvanttm ssrsrnttaa dtynitdpee leteypffes rvdnkertvi snlrpftlyr idihscnhea eklgcsasnf vfartmpaeg addipgpvtw eprpensifl kwpepenpng lilmyeikyg sqvedqrecv srqeyrkygg aklnrlnpgn ytariqatsl sgngswtdpv ffyvqaktgy enhhhhhhhh hh

N-terminal Sequence Analysis
Glu31 and Asp 741
State of Matter
Lyophilized
Predicted Molecular Mass
The predicted molecular weight of Recombinant Human IGF-I sR is Mr 81, 23, 104 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 150, 120, 48 kDa.
Predicted Molecular Mass
81, 23, 104
Storage and Stability
This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.
Country of Origin
USA
Shipping
Next Day Ambient

References & Citations

1. Riedemann, J. and Macaulay, VM. et al. (2006) Endocrine-Related Cancer 13(1):S33-43
2. Le Bouc, Y. et al. (2003) Nature. 421(6919):182-7.

Certificate of Analysis

IMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein.
Disclaimer AlertProducts are for research use only. Not for use in diagnostic or therapeutic procedures.