Recombinant Human Myostatin
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BackgroundMyostatin (Mstn)is a secreted growth and differentiating factor (GDF-8) that belongs to the transforming growth factor-beta (TGF-beta) superfamily.1 It is expressed specifically in developing and mature skeletal muscle and appears to act as a negative regulator of muscle development.2 Myostatin plays a significant, direct role in bone formation and regeneration.3 Protein DetailsPurity >95% by SDS Page and HPLC Endotoxin Level <1.0 EU/µg as determined by the LAL method Biological Activity The biological activity of Human Myostatin was determined by the inhibition of the prolifiration of MPC-11 cells. The expected ED<sub>50</sub> is < 20 ng/ml. Protein Accession No. O14793(267-375) Amino Acid Sequence DFGLDCDEHS TESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGECEFV FLQKYPHTHL VHQANPRGSA GPCCTPTKMS PINMLYFNGK EQIIYGKIPA MVVDRCGCS State of Matter Lyophilized Predicted Molecular Mass The molecular weight of Recombinant Human Myostatin is Mr 25 kDa. Storage and Stability The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient NCBI Gene Bank References & Citations1. Bass, JJ. et al. (1999) J Cell Physiol. 180: 1 2. Smith, TP. et al. (2001) Anim. Genet. 29: 19 3. Hamrick, MW. et al. (2009) Bone 44: 17 Certificate of AnalysisIMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein. |
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