Recombinant Human NAP-2 (CXCL7)

CXC chemokine ligand 7 is a small cytokine belonging to the CXC chemokine family. It is a protein that is released in large amounts from platelets following their activation.¹ It stimulates various processes including mitogenesis, synthesis of extracellular matrix, glucose metabolism and synthesis of plasminogen activator.^2,3

The biological activity of Human CXCL7 was determined by its induction of myeloperoxidase release from cytochalasin B treated human neutrophils (Schröder, J. et al., 1987 J. Immunol. 139:3474) or chemotaxis of BaF/3 hCXCR-2 transfected cells. The expected ED₅₀ for this effect is typically 0.1 - 0.3 μg/ml, or 0.1 - 0.5 ng/ml, respectively.

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Ala59

Lyophilized

The predicted molecular weight of Recombinant Human CXCL7 is Mr 7.6 kDa.

7.6

This recombinant protein was lyophilized from a 0.2 μm filtered solution in 30% acetonitrile (CH₃CN) and 0.1% trifluoroacetic acid (TFA).

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

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1. Poncz, M. et al. (1991) J Biol Chem. 266: 5785
2. Walz, D. et al. (1983) Proc Natl Acad Sci USA 80: 765
3. Carter-Su, C. et al. (1985) Biochemistry 24: 1762