Recombinant Human Neurturin

Neurturin (NRTN) is a potent neurotrophic factor.¹ NRTN supports the survival of cultured sympathetic neurons and sensory neurons of the nodose and dorsal root ganglia. Neurturin is structurally related to GDNF (Glial cell line-derived neurotrophic factor).² NRTN has been demonstrated to act specifically on mesencephalic dopaminergic neurons, suggesting its therapeutic potential for Parkinson's disease (PD).³

The biological activity of Human NRTN was determined by its ability to support survival of a majority of newborn Rat Sympathetic neurons at a concentration of 100 ng/ml.

Lyophilized

The predicted molecular weight of Recombinant Human NRTN, which consists of two disulfide linked homodimers, is Mr 23.6 kDa.

22.6

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Milbrandt, J. et al. (1997) Genomics 44: 137
2. Kotzbauer et al. (1996) Nature 384: 467
3. Chen, SD. et al. (2007) Molec. Neurodegeneration 2: 19