Recombinant Human NGF R

Nerve growth factor receptor (NGFR), also known as the low-affinity receptor p75NTR is a transmembrane glycoprotein without intrinsic tyrosine kinase activity, whose expression is not restricted to neural cells. NGFR is reported to act as a tumour suppressor, negatively regulating cell growth and proliferation.¹ It is also involved in several diverse functions such as apoptosis, neurite outgrowth during development, and myelination.² p75NGFR contributes to delayed neuronal death (DND) after ischemia by an apoptotic mechanism.³

Fc Fusion Protein

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Lys29

Lyophilized

The predicted molecular weight of Recombinant Human NGFR is Mr 51 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 70-80 kDa.

51

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Ashworth, A. et al. (2006) Modern Path. 19: 307
2. Carter, BD. et al. (2004) Prog. Brain Res. 146: 25
3. Itano, T. et al. (2001) Acta Med Okayama 55: 19