Recombinant Human NOV

Nephroblastoma overexpressed gene, also known as NOV is a member of the CCN (connective tissue growth factor [CTGF]) family of proteins. These proteins are cysteine-rich and are noted for having growth-regulatory functions.¹ NOV is highly expressed in the nervous system.² NOV is a specific cell fate regulator in the myogenic lineage, acting negatively on key myogenic genes thus controlling the transition from progenitor cells to myoblasts.³ NOV also supports endothelial cell adhesion and angiogenesis through interactions with integrins.⁴

Lyophilized

The predicted molecular weight of Recombinant Human NOV is Mr 37.1 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 55 kDa.

37.1

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Maki RA. et al. (1999) Gene 238: 471 2. Kleinman HK. et al. (2003) FASEB J. 17: 1919 3. Dubois C. et al. (2006) Exp Cell Resp. 312: 1876 4. Martinerie C. et al. (2005) Cell Commun Adhes. 12: 41