Recombinant Human OTOR
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BackgroundOtoraplin, also known as OTOR is a secreted cytokine that is expressed predominantly in the cochlea of the inner ear and to a lesser extent in fetal brain and in some cartilage tissues. OTOR may play a role in chondrogenesis of the otic capsule as reduction of its expression by suitable antisense oligonucleotides causes a significant reduction in chondrogenesis.1 Otoraplin is homologous to the protein encoded by CDRAP/MIA (cartilage-derived retinoic acid sensitive protein/melanoma inhibitory activity), which is expressed predominantly by chondrocytes, functions in cartilage development and maintenance, and has growth-inhibitory activity in melanoma cell lines.2 Protein DetailsPurity >95% by SDS Page and HPLC Endotoxin Level <0.1 EU/µg as determined by the LAL method Amino Acid Sequence MVHGIFMDRL ASKKLCADDE CVYTISLASA QEDYNAPDCR FINVKKGQQI YVYSKLVKEN GAGEFWAGS VYGDGQDEMG VVGYFPRNLV KEQRVYQEAT KEVPTTDIDF FCE State of Matter Lyophilized Predicted Molecular Mass The molecular weight of Recombinant Human OTOR is Mr 12.7 kDa. Storage and Stability The lyophilized protein should be stored desiccated at -20°C. For long-term storage of the reconstituted protein, it is recommended to add a carrier protein such as 0.1% BSA, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient References & Citations1. Cohen-Salmon M. et al. (2000) J of Biol. Chem. 275: 40036
2. Morton CC. et al. (2000) Genomics 66: 242
Certificate of AnalysisIMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein. |
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Products are for research use only. Not for use in diagnostic or therapeutic procedures.
