Recombinant Human PDGF-CC

The platelet-derived growth factor (PDGF) family of heparin-binding growth factors consists of five known members, denoted PDGF-A, -B, -C and –D that form disulfide-linked homodimers and one heterodimer. PDGF-CC is expressed in actively angiogenic tissues such as placenta, some embryonic tissues and tumors (1). It induces fibroblast reactivity and fibrosis in a wide range of tissues (2). PDGF-CC interacts with two related protein tyrosine kinase receptors, PDGFR-α and PDGFR-β. Delivery of PDGF-CC enhanced post ischemic revascularization of the heart and limb, therefore, modulating the activity of PDGF-CC may provide novel opportunities for treating ischemic diseases (3). PDGF-CC has been shown to be a potent neuroprotective factor that acts by regulating glycogen synthase kinase 3β activity (4).

Histidine Tag

vvdlnl lteevrlysc tprnfsvsir eelkrtdtif wpgcllvkrc ggncacclhn cnecqcvpsk vtkkyhevlq lrpktgvrgl hksltdvale hheecdcvcr gstgghhhhh h

Met

Lyophilized

The predicted molecular weight of Recombinant Human PDGF-CC is Mr 13.4 kDa.

13.4

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Cao, Y. et al. (2002) FASEB J. 16:1575
2. Pietras, K. et al. (2009) Cancer Res. 69:369
3. Li, X. et al. (2005) J. Clin. Investig. 115:118
4. Li, X. et al. (2010) J. Exp. Med. 4:867