Recombinant Human PK2

Prokineticin 2 (PK2) is a cysteine-rich secreted protein¹ that is expressed in the testis and in lower levels of the small intestine. PK2 regulates various biological functions including gastrointestinal motility, angiogenesis, circadiam rhythms, and neurogenesis of olfactory bulb.² It is closely related to EG-VEGF (Prokineticin-1) and binds to two orphan B-protein-coupled receptors termed PK-R1 and PK-R2. PK2 plays roles in both circadian and homeostatic regulation of sleep. PK2 may also be involved in maintaining the awake state in the presence of behavioral challenges.³

Data not yet available.

AVITGACDKD SQCGGGMCCA VSIWVKSIRI CTPMGKLGDS CHPLTRKVPF FGRRMHHTC PCLPGLACLR TSFNRFICLA QK

The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

1. Zhou QY et al. (2002) Nature 417: 405 2. Zhou QY et al. (2007) J Biol Chem. 282: 6917 3. Zhou QY et al. (2007) Sleep 30: 247