Recombinant Human PTHrP

Parathyroid hormone-related protein (PTHrP) is a family of protein hormones produced by most if not all tissues in the body. It is secreted from a large and diverse set of cells, and during both fetal and postnatal life. Among tissues known to secrete this hormone are several types of epithelium, mesenchyme, vascular smooth muscle and central nervous system.^1,2 PTHrP is secreted from smooth muscle in many organs, usually in response to stretching. It acts to relax smooth muscle, thereby serving, among other things, as a vasodilating hormone. PTHrP may also have effects on contraction of muscle in the bladder, uterus and heart^1,2 and can play crucial roles in the cardiovascular system.³ PTHrP regulates proliferation and differentiation within the postnatal, cranial growth plate.⁴ PTHrP has been shown to have anabolic effects in women with postmenopausal osteoporosis. PTHrP promotes the recruitment of osteogenic cells and prevents apoptotic death of osteoblasts and osteocytes.⁵ PTHrP is a causative factor of humoral hypercalcemia of malignancy (HHM). It also causes cachexia including reduced food intake, body weight loss, and decreased locomotor activity by a mechanism that is independent of hypercalcemia and proinflammatory cytokine actions.⁶

Data not yet available.

AVSEHQLLHD KGKSIQDLRR RFFLHHLIAE IHTAEIRATS EVSPNSKPSP NTKNHPVRFG SDDEGRYLTQ ETNKVETYKE QPLKTP

The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

1. Strewler, GJ. et al. (2000) New Eng J Med. 342: 177
2. Stewart, AF. et al. (1998) Annu Rev Physiol. 40: 431
3. Helwig, JJ. et al. (1998) Curr Opin Nephrol Hypertens. 7: 27
4. Wealthall, RJ. et al. (2009) J Cell Physiol.
5. Lamberg-Allardt, C. et al. (2009) Steroids 74: 277
6. Okabe, H. et al. (2008) Clin Calcium 18: 489