Recombinant Human Resistin

Resistin is a cysteine-rich protein secreted by adipose tissue of mice and rats. In other mammals, at least primates, pigs and dogs, resistin is secreted by immune and epithelial cells. Resistin is also known as CEBPE regulated myeloid-specific secreted cysteine-rich protein precursor 1 (XCP1), found in inflammatory zone 3 (FIZZ3), or "adipocyte-specific secretory factor" (ADSF). The length of the resistin pre-peptide in human is 108 aminoacids (in the mouse and rat it's 114 aa). Among the proteins synthesized and released from adipose tissue (adiponectin, angiotensin, estradiol, IL-6 [disambiguation needed], leptin, PAI-1, TNF-α), resistin is a cytokine whose physiologic role has been the subject of much controversy regarding its involvement with obesity and type II diabetes mellitus (T2DM).

The biological activity of Human Resistin was determined its ability to stimulate lipolysis in human adipocytes.

MSSKTLCSME EAINERIQEV AGSLIFRAIS SIGLECQSVT SRGDLATCPR GFAVTGCTCG SACGSWDVRA ETTCHCQCAG MDWTGARCCR VQP

Lyophilized

The predicted molecular weight of Recombinant Human Resistin is Mr 19.5 kDa.

19.5

This recombinant protein was lyophilized from a 0.2 μm filtered solution of 0.1% trifluoroacetic acid (TFA).

The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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