Recombinant Human TFF2

Trefoil factor 2 (TFF2), also known as spasmolytic protein 1 is a small secreted protein¹ and a member of the trefoil family of peptides. It is a highly stable peptide which is abundantly expressed and secreted by mucous cells of the stomach and has a functions in gastric cytoprotection.² TFF2 is also detected at high concentrations around sites of ulceration. It is protective against mucosal damaging agents and stimulates cell motility.¹ TFF2 is also useful in the treatment of colitis.³

The biological activity of Human Recombinant Human Trefoil Factor 2 is determined by its ability to chemoattract human monocytes using a concentration range of 1.0-10.0 µg/ml.

EKPSPCQCSR LSPHNRTNCG FPGITSDQCF DNGCCFDSSV TGVPWCFHPL PKQESDQCVM EVSDRRNCGY PGISPEECAS RKCCFSNFIF EVPWCFFPKS VEDCHY

The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

1. Westley BR et al. (2000) Gut 46: 454 2. Wang TC et al. (2002) Biochemical and biophysical research communications 293: 366 3. Panés J. et al. (2004) J Leukoc Biol. 75: 214