Recombinant Human Thrombopoietin

Thrombopoietin (leukemia virus oncogene ligand, megakaryocyte growth and development factor), also known as THPO is a lineage-dominant hematopoietic cytokine.¹ TPO is a glycoprotein hormone constitutively produced mainly by the liver and kidney and is the primary physiological regulator megakaryopoiesis² and platelet production.¹

spappacdl rvlskllrds hvlhsrlsqc pevhplptpv llpavdfslg ewktqmeetk aqdilgavtl llegvmaarg qlgptclssl lgqlsgqvrl llgalqsllg tqlppqgrtt ahkdpnaifl sfqhllrgkv rflmlvggst lcvrrapptt avpsrtslvl tlnelpnrts glletnftas arttgsgllk wqqgfrakip gllnqtsrsl dqipgylnri hellngtrgl fpgpsrrtlg apdissgtsd tgslppnlqp gyspspthpp tgqytlfplp ptlptpvvql hpllpdpsap tptptsplln tsythsqnls qeg

Ser22

Lyophilized

The predicted molecular weight of Recombinant Human TPO is Mr 35 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 80-90 kDa.

35

This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Vainchenker, W. et al. (1998) Eur Cytokine Newt. 9: 221
2. Skoda, RC. et al. (1998) Blood 92: 4023