Recombinant Human Vaspin

Visceral adipose tissue-derived serpin (vaspin) is a novel adipokine related to obesity and its metabolic consequences.¹ Vaspin is a member of serine protease inhibitor family.² Its levels increase with hyperinsulinemia and obesity.³ vaspin exerts an insulin-sensitizing effect targeted toward white adipose tissues (WAT) in states of obesity.²

MLKPSFSPRN YKALSEVQGW KQRMAAKELA RQNMDLGFKL LKKLAFYNPG RNIFLSPLSI STAFSMLCLG AQDSTLDEIK QGFNFRKMPE KDLHEGFHYI IHELTQKTQD LKLSIGNTLF IDQRLQPQRK FLEDAKNFYS AETILTNFQN LEMAQKQIND FISQKTHGKI NNLIENIDPG TVMLLANYIF FRARWKHEFD PNVTKEEDFF LEKNSSVKVP MMFRSGIYQV GYDDKLSCTI LEIPYQKNIT AIFILPDEGK LKHLEKGLQV DTFSRWKTLL SRRVVDVSVP RLHMTGTFDL KKTLSYIGVS KIFEEHGDLT KIAPHRSLKV GEAVHKAELK MDERGTEGAA GTGAQTLPME TPLVVKIDKP YLLLIYSEKI PSVLFLGKIV NPIGK

The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

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1. Blüher, M. et al. (2008) Atherosclerosis
2. Kanwar, YS. et al. (2005) Proc Natl Acad Sci USA 102: 10610
3. Randeva, HS. et al. (2008) Diabetes 57: 1501