Recombinant Human VEGF-C
Recombinant Human VEGF-C
Product No.: V128
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Alternate Names VEGF-Vascular Endothelial Growth Factor-C2, Flt-4 Ligand, Vascular Endothelial Related Growth Factor Related Protein (VPR), Cys156Ser Product Type Recombinant Protein Expression Host CHO Cells Species Human Applications ELISA Cap |
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BackgroundVascular endothelial growth factor C (VEGF-C) is a member of the VEGF family and is known to be associated with angiogenesis and lymphangiogenesis in various cancers.1 VEGF-C plays a key role in the physiology and pathology of many aspects of the cardiovascular system, including vasculogenesis, hematopoiesis, angiogenesis and vascular permeability.2 VEGF-C may participate in the development and progression of angiogenic diseases.3 Protein DetailsPurity >95% by SDS-PAGE and analyzed by silver stain. Endotoxin Level <0.1 EU/µg as determined by the LAL method Biological Activity Measured in a cell proliferation assay the The ED<sub>50</sub> for this effect is 1.5-9 ng/mL. Fusion Protein Tag Fc Fusion Protein Protein Accession No. Amino Acid Sequence MAHYNTEILK SIDNEWRKTQ CMPREVCIDV GKEFGVATNT FFKPPCVSVY RCGGCCNSEG LQCMNTSTSY LSKTLFEITV PLSQGPKPVT ISFANHTSCR CMSKLDVYRQ VHSIIRR N-terminal Sequence Analysis Ala112 State of Matter Lyophilized Predicted Molecular Mass The predicted molecular weight of Recombinant Human VEGF-C is Mr 13 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 13 - 20 kDa. Predicted Molecular Mass 13 Formulation The protein was 0.2 µm filtered and lyophilized from PBS. Storage and Stability This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. Country of Origin USA Shipping Next Day Ambient NCBI Gene Bank References & Citations1. Ishida, H. et al. (2008) Jpn J Clin Oncol. 38: 839 2. Peppers, MS. et al. (1999) J Soc Biol. 193: 159 3. Alitalo, K. et al. (1998) Proc Natl Acad Sci USA 95: 14389 Technical Protocols Certificate of AnalysisIMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein. |
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