Recombinant Mouse APRIL (A Proliferation-Inducing Ligand)

A proliferation-inducing ligand (APRIL) is a TNF-like cytokine that stimulates tumor cell growth.¹ It is of low abundance in normal tissues.² APRIL acts as a proliferative factor in megakaryocytopoiesis, a developmental hematopoietic process responsible for progenitor cell differentiation to megakaryoblasts and megakaryocytes, leading to platelet formation.³ APRIL may be implicated in the regulation of tumor cell growth.²

The biological activity of Mouse APRIL is measured by its ability to induce cell proliferation of activated T cells.

MRREVSRLQR SGGPSQKQGE RPWQSLWEQS PDVLEAWKDG AKSRRRRAVL TQKHKKKHSV LHLVPVNITS KDSDVTEVMW QPVLRRGRGL EAQGDIVRVW DTGIYLLYSQ VLFHDVTFTM GQVVSREGQG RRETLFRCIR SMPSDPDRAY NSCYSAGVFH LHQGDIITVK IPRANAKLSL SPHGTFLGFV KL

The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

1. Hymowitz, SG. et al. (2004) J Mol Biol. 343: 283
2. (1998) Jürg Tschopp
3. De Maria, R. et al. (2004) Blood 104: 3169