Recombinant Mouse IL-1 RII
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BackgroundInterleukin 1 receptor type II (IL1R2), also known as CD121b (Cluster of Differentiation 121b), is a transmembrane protein found on B lymphocytes, neutrophils, monocytes, large granular leukocytes and endothelial cells. It is a decoy receptor known for its ability to buffer IL-1 effects.1 IL-1RII is involved in the control of the proinflammatory state that takes place in the endometrium during the premenstrual and menstrual periods.2 IL-1RII can neutralize IL-1 beta and counteract its effect on endometrial stromal cells, and may provide a new clinical strategy for the treatment of endometriosis.3 Protein DetailsPurity >95% by SDS-PAGE and analyzed by silver stain. Endotoxin Level <0.1 EU/µg as determined by the LAL method Fusion Protein Tag Fc Fusion Protein Protein Accession No. Amino Acid Sequence fttptvv htgkvsespi tsekptvhgd ncqfrgrefk selrlegepv vlrcplaphs disssshsfl twskldssql iprdeprmwv kgnilwilpa vqqdsgtyic tfrnashceq msvelkvfkn teaslphvsy lqisalsttg llvcpdlkef issnadgkiq wykgailldk gnkeflsagd ptrllisnts mddagyyrcv mtftyngqey nitrnielrv kgtttepipv iispletipa slgsrlivpc kvflgtgtss ntivwwlans tfisaayprg rvteglhhqy sendenyvev slifdpvtre dlhtdfkcva snprssqslh ttvkeiegrm
dpkscdktht cppcpapell ggpsvflfpp kpkdtlmisr tpevtcvvvd vshedpevkf nwyvdgvevh naktkpreeq ynstyrvvsv ltvlhqdwln gkeykckvsn kalpapiekt iskakgqpre pqvytlppsr deltknqvsl tclvkgfyps diavewesng qpennykttp pvldsdgsff lyskltvdks rwqqgnvfsc svmhealhnh ytqkslslsp gk
N-terminal Sequence Analysis Phe14 State of Matter Lyophilized Predicted Molecular Mass The predicted molecular weight of Recombinant Mouse IL-1 RII is Mr 64.7 kDa. However, the actual molecular weight as observed by migration on SDS-PAGE is Mr 70-80 kDa. Predicted Molecular Mass 64.7 Formulation This recombinant protein was 0.2 µm filtered and lyophilized from modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives.
Storage and Stability This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions. Country of Origin USA Shipping Next Day Ambient NCBI Gene Bank References & Citations1. Akoum, A. et al. (2005) Hum Rep. 20: 1177 2. Akoum, A. et al. (2001) Biol Rep. 65: 890 3. Liu, J. et al. (2008) Fertil Steril. 89: 42 Certificate of AnalysisIMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein. |
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