Recombinant Mouse IL-17E
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BackgroundIL-17E, also known as IL-25, is a novel member of the IL-17 family of cytokines1 and a unique pleiotropic cytokine and may be an important mediator of inflammatory and immune responses.2 IL-17E has a heterodimeric receptor. The receptor is composed of two subunits IL-17RA and IL-17RB. Although IL-17E only binds IL-17RB directly, both subunit receptors are essential for IL-17E functions. IL-17E induces activation of NF-κB and stimulates production of the proinflammatory chemokine IL-8. 1 IL-17E may contribute to the induction and maintenance of eosinophilic inflammation in the airways by acting on lung fibroblasts and therefore has a role in asthma pathophysiology.3 Protein DetailsPurity >95% by SDS-PAGE and HPLC Endotoxin Level <0.1 EU/µg as determined by the LAL method Protein Accession No. State of Matter Lyophilized Predicted Molecular Mass The molecular weight of Recombinant Mouse IL-17E is Mr 35.5 kDa. Country of Origin USA Shipping Next Day Ambient NCBI Gene Bank Certificate of AnalysisIMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein. |
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