Recombinant Mouse IL-28A

Interleukin-28A (IL-28A) also known as IFNL2 is a novel cytokine that exerts its biological effects through a receptor that also binds IL28B and IL29. IL28A induces phosphorylation of STAT1, STAT2, and STAT3¹ IL-28A has antiviral activities and stimulates antiviral responses through a heterodimeric receptor. IL-28A represents a potential novel approach for therapy of Th1-mediated inflammatory diseases such as T-cell-mediated hepatitis.²

The biological activity of Mouse IL-28A was determined its ability to activate STAT following receptor - ligand interaction.

MDPVPRATRL PVEAKDCHIA QFKSLSPKEL QAFKKAKDAI EKRLLEKDMR CSSHLISRAW DLKQLQVQER PKALQAEVAL TLKVWENMTD SALATILGQP LHTLSHIHSQ LQTCTQLQAT AEPKPPSRRL SRWLHRLQEA QSKETPGCLE DSVTSNLFRL LTRDLKCVAS GDQCV

Lyophilized

The predicted molecular weight of Recombinant Mouse IL-28A is Mr 20.5 kDa. However, the actual molecular weight as observed by migration on SDS Page is Mr 25-30 kDa.

20.5

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

1. Zitzmann K. et al.(2006) Biochem. Biophys. Research Commun. 344: 1334 2. Neurath Markus F. et al.(2007) Gastroenterology 132: 358