Recombinant Mouse PDGF-AA

Platelet-derived growth factor (PDGF), an agent with important mitogenic effects for bone cells, exists in three isoforms, PDGF-AA, - BB, and –AB.¹ The A-chain homodimers of the platelet-derived growth factor (PDGF AA) are widely expressed in normal and transformed cells.² PDGF AA is a potent mitogen for a wide range of cell types including fibroblast, smooth muscle, and connective tissue. PDGF-AA and its receptor represent an important epithelial-mesenchymal interaction which plays a critical role in early lung branching morphogenesis.³ PDGF AA is also an essential autocrine regulator for vascular endothelial growth factor (VEGF) expression. It regulates the frequency and level of VEGF expression during the transition from a precancerous lesion to advanced cancer.⁴

Lyophilized

The predicted molecular weight of Recombinant Mouse PDGF-AA is Mr 28.9 kDa.

28.9

The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Next Day Ambient

1. Canalis, E. et al. (1994) Endocrin. 134: 2541
2. Deuel, TF. et al. (1992) Biochem Biophys Res Commun. 186: 1510
3. Post, M. et al. (1995) Endocrin. 121: 25529
4. Sueishi, K. et al. (2005) Cancer Research 65: 7241