Recombinant Mouse Persephin

Lyophilized

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

Next Day Ambient

The DNA sequence encoding the TGF-β-like domain of mouse Persephin (Ala 61 - Gly 156) was inserted into a suitable expression vector and was expressed in E. coli (Tomac, A.C. et al., 2002, Proc. Natl. Acad. Sci. USA 99:9521 - 6526).

Persephin (PSP) is a secreted protein belonging to the glial cell line-derived neurotrophic factor (GDNF) family of the TGF-b superfamily. Just like factor GDNF and neurturin (NTN), PSP promotes the survival of ventral midbrain dopaminergic neurons and prevents their degeneration. Persephin also supports the survival of motor neurons.¹ Persephin is expressed at very low levels in most tissues. It is synthesized throughout the nervous system and has both astroglial and neuronal origin.²

1. Johnson, EM. et al. (1998) Neuron 20: 2452. Krieglstein K. et al. (1998) J Neurosci Res. 53: 494