Recombinant Mouse Thrombopoietin (E. Coli Expressed)
Recombinant Mouse Thrombopoietin (E. Coli Expressed)
Product No.: T646
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Alternate Names THPO, MGC163194, Megakaryocyte Growth and Development Factor (MGDF), MKCSF, ML, MPLLG, MpI Ligand Product Type Recombinant Protein Expression Host E. coli Cells Species Mouse |
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BackgroundThrombopoietin (leukemia virus oncogene ligand, megakaryocyte growth and development factor), also known as THPO is a lineage-dominant hematopoietic cytokine.1 TPO is a glycoprotein hormone constitutively produced mainly by the liver and kidney and is the primary physiological regulator megakaryopoiesis2 and platelet production.1 Protein DetailsBiological Activity The biological activity of Mouse TPO was determined by a cell proliferation assay using MO7e cells (Avanzi, G. et al., 1988, Br. J. Haematol. 69:359). The expected ED<sub>50</sub> for this effect is typically 1 - 3 ng/ml. Protein Accession No. Amino Acid Sequence SPVAPACDPR LLNKLLRDSH LLHSRLSQCP DVDPLSIPVL LPAVDFSLGE WKTQTEQSKA QDILGAVSLL LEGVMAARGQ LEPSCLSSLL GQLSGQVRLL LGALQGLLGT QLPLQGRTTA HKDPNALFLS LQQLLRGKVR FLLLVEGPTL CVRRTLPTTA VPSSTSQLLT LNKF State of Matter Lyophilized Predicted Molecular Mass The molecular weight of Recombinant Mouse TPO is Mr 18.7 kDa. Formulation This recombinant protein was 0.2 µm sterile filtered and lyophilyzed in PBS pH 7.4 with no preservatives or additives. Storage and Stability The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient NCBI Gene Bank References & Citations1. Vainchenker W et al. (1998) Eur Cytokine Newt. 9: 221
2. Skoda RC et al. (1998) Blood 92: 4023 Certificate of AnalysisIMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein. |
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