Recombinant Mouse GDNF
- -
- -
BackgroundGlial cell derived neurotrophic factor, also known as GDNF is a glycosylated, disulfide-bonded homodimer that is a distantly related member of the transforming growth factor-beta superfamily.1 GDNF potently promotes the survival of many types of neurons, most prominently, dopaminergic and motorneurons. GDNF regulates kidney development and spermatogenesis, and it affects alcohol consumption.2 Protein DetailsPurity >98% by SDS-PAGE and HPLC Endotoxin Level <1.0 EU/µg Biological Activity The biological activity of mouse GDNF is determined by the proliferation of rat C6 cells. The ED<sub>50</sub> is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 X 10<sup>6</sup> units/mg. Protein Accession No. Amino Acid Sequence MSPDKQAAAL PRRERNRQAA AASPENSRGK GRRGQRGKNR GCVLTAIHLN VTDLGLGYET KEELIFRYCS GSCESAETMY DKILKNLSRS RRLTSDKVGQ ACCRPVAFDD DLSFLDDNLV YHILRKHSAK RCGCI
State of Matter Lyophilized Storage and Stability The lyophilized protein should be stored desiccated at -20°C. The reconstituted protein can be stored for at least one week at 4°C. For long-term storage of the reconstituted protein, aliquot into working volumes and store at -20°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. Country of Origin USA Shipping Next Day Ambient NCBI Gene Bank References & Citations1. Collins, F. et al. (1993) Science 260: 1130 2. Ron, D. et al. (2008) Proc. Natl. Acad. Sci. U.S.A. 105: 8114 Certificate of AnalysisIMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein. |
Related Products
- -
- -
Prod No. | Description |
|---|---|
G120 | |
G638 |
Products are for research use only. Not for use in diagnostic or therapeutic procedures.
