Recombinant Rat GM-CSF
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BackgroundGranulocyte-Macrophage Colony Stimulating Factor is a 22 kD, pleiotropic cytokine that is a white blood cell growth factor. It controls the production and function of blood cells by stimulating stem cells to produce granulocytes and monocytes. GM-CSF differs from G-CSF in that it affects more cell types including macrophages and eosinophils. Moreover, GM-CSF is part of the immune/inflammatory cascade, a process crucial for fighting infection. Interestingly, GM-CSF expression may have pathological implications. Autocrine expression of GM-CSF in myeloid leukemia cells is suspected to play a role in neoplasia, the formation of a new and abnormal growth of tissue. Additionally, GM-CSF expression has also been documented in certain solid tumors. There have also been reports of GM-CSF in synovial fluid from patients with arthritis suggesting that GM-CSF may play a role in tissue damage associated with the inflammatory process. Blocking GM-CSF is thought to have therapeutic potential by reducing inflammation. Some drugs are currently being developed to block GM-CSF. Protein DetailsPurity >97% by SDS-PAGE and analyzed by silver stain. Endotoxin Level <0.1 EU/µg as determined by the LAL method Protein Accession No. Amino Acid Sequence aptrspnpvt rpwkhvdaik ealsllndmr aleneknedv diisnefsiq rptcvqtrlk lykqglrgnl tklngaltmi ashyqtncpp tpetdceiev ttfedfiknl kgflfdipfd cwkpvqk
N-terminal Sequence Analysis Met & Ala1 State of Matter Solution Predicted Molecular Mass The predicted molecular weight of Recombinant Rat GM-CSF is Mr 14.7 kDa. Predicted Molecular Mass 14.7 Formulation This recombinant protein solution was 0.2 µm filtered and formulated in modified Dulbecco’s phosphate buffered saline (1X PBS) pH 7.2 – 7.3 with no calcium, magnesium, or preservatives present. Storage and Stability Working aliquots of this recombinant protein solution are stable for up to twelve months at -20°C to -70°C in a manual defrost freezer. Upon thawing, in the presence of a carrier protein, this recombinant protein can be stored at 2° - 8°C for one month without detectable loss of activity. For long-term storage, aliquot and freeze at -20°C to -70°C in a manual defrost freezer. Avoid repeated freeze thaw cycles. Country of Origin USA Shipping Dry Ice NCBI Gene Bank References & Citations1. Parker, MW. et al. (2008) Cell 134: 496 2. Trapnell, BC. and Whitsett, JA. (2002) Annual Review of Physiology 64: 775 Certificate of AnalysisIMPORTANT Use lot specific datasheet for all technical information pertaining to this recombinant protein. |
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