Recombinant Rat IL-18

Interleukin-18 is a member of the interleukin-1 family of cytokines with pro-inflammatory and tumor-suppressive properties. Its ability to potently enhance the production of interferon-gamma indicates in particular the crucial function of interleukin-18 as an immunomodulatory molecule. In fact, high levels of interleukin-18 are detected in human diseases associated with immunoactivation including viral or bacterial infections and chronic inflammation. Animal models suggest suppression of interleukin-18 bioactivity as a novel therapeutic concept specifically for the treatment of chronic inflammatory diseases such as rheumatoid arthritis, Crohn's disease, and psoriasis. It is the only cytokine with a unique capacity to induce T helper 1 or T helper 2 polarization, depending on the immunologic context.

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Met

Lyophilized

The predicted molecular weight of Recombinant Rat IL-18 is Mr 18.4 kDa.

18.4

This recombinant protein was lyophilized from a 0.2 μm filtered solution in MOPS, EDTA, Dithiothreitol (DTT), and sodium sulphate (Na₂SO₄).

This lyophilized protein is stable for six to twelve months when stored desiccated at -20°C to -70°C. After aseptic reconstitution, this protein may be stored at 2°C to 8°C for one month or at -20°C to -70°C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles. See Product Insert for exact lot specific storage instructions.

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1. Pitzalis C. et al. (2007) Expert Opin Biol Ther. 7(1):31-40.
2. Arranz, E. et al. (2006) Clin Exp Immunol. 146(3):479-85.
3. DeMatteo, RP. et al. (2006) Cancer Res. 66(21):10497-504.
4. Torre, D and Pugliese, A. (2006) Curr HIV Res. 4(4):423-30.
5. Feick, P. et al. (2006) World J Gastroenterol.12(40):6507-14.
6. Song, YW. et al. (2006) Hum Immunol. 67(10):812-8.